Breeder reactors could, in principle, extract almost all of the energy contained in uranium or thorium, decreasing fuel requirements by a factor of 100 compared to traditional once-through light water reactors.
The uranium-235 isotope is the nuclear fuel used for energy generation via nuclear fission of in a typical power reactor. Each kilogram of uranium-235 fissioned releases the energy equivalent of millions of times its mass in chemical reactants, as much energy as 2700 tons of coal, but uranium-235 is only 0.7% of the mass of natural uranium.
The 235U consumption (linked to various factors as electricity generated by nuclear power plants, population growth, oil and coal consumption, etc) will lead to vanishing of U enriched ores in the near future.