In one of the scientific paper on dissolution testing where the dissolution test was performed at 25 °C and at 47 °C. What could be the rationale for using these temperatures instead of 37 °C?
Nizar Matar
I guess the authors of the scientific paper might have seen dissolution tests in the chemical literature at various temperature ranges other than what they applied in their study.
Another possibility is that up to 47 oC, the solute/solvent interaction is purely physical but beyond this T there may be some chemical change.
It is difficult for me to accept a haphazard choice of T range in research.
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Kamran Zaheer
They may be searching for the thermodynamic equivalence for bioequivalence.
It was coined in 2016.
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