Dear Veda,
Let me see if I understood your question. Large platelets, also known as macroplatelets may not be identified by the Coulter. Conditions that increase the production of platelets, such as bleeding, ITP, or hypersplenism may be accompanied by large platelets. In these conditions, visual observation is required to confirm the presence of large platelets.
proper mixing of sample is one of the major step in cell counting . if not mixed properly platelets form clumps which will not be counted as platelets.
Dear Veda,
This paper may interest you: CAUSES OF VARIATION IN THE PLATELET COUNT
EXPERIMENTAL RESULTS SHOWING THE EFFECT OF DIPHTHERIA TOXIN, BENZOL AND TUBERCULIN ON THE PLATELET COUNT IN RABBITS
WILLIAM W. DUKE, M.D.
Arch Intern Med (Chic). 1913;XI(1):100-120.
It is known thtat there is negatively correlated between platelet count and MPV values, the MPV values are higher in summer than in winter ,pseudothrombocitopenia is induced by EDTA K3 by inmmunoglobulin that induces platelet clumping by antibody against gp-IIb IIIa that recognoizes fibrinogen and Von Willebrand factor binding site .Platelets change thieir shape from discoid to spheroid with filamentous extension remaining unchanged for 1-2 hours but platelet count diminishes 10 % in 4 hs and 15 % in 24 hs. In my experience.
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