The charge, biocompatibility of selected dendritic carrier can be very interesting as a carrier for antimalarial drug targeting.
Article Amphiphilic dendritic derivatives as nanocarriers for the ta...
Covalent attachment of Drugs to polymer chains via specific
linkers,biocompatibility,biodegradability along with other standard requisites like charge,specificity etc. are some of the specification criteria required as a carrier for antimalarial drug targeting.
So continuing the discussion, its important to understand where the parasite comes from and where it reaches and harbors. Mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. These parasites travel to reach liver where they mature and reproduce.
Now, what should be the Nano-Dendritic polymeric carriers engineered as a carrier to deliver antimalarial agents effectively ?
As such dendritic carriers are positively charged mostly (also neutral and negative charged can be taken into consideration), they present themselves as potential toxic entities if charged not controlled appropriately. Thus from my end "charge shielding" or or / and "charge optimization" on the carrier is required to be specified.
Further, dendritic carriers get readily solubilized in plasma pool and show prolong reterntion sometimes that leads to its potential for antimalarial therapy. Till this its ok.. but what about its biocompatibility. Here we can agree with what Dr Anil Sharma stated about opting linkers (might be like Macrogol type linkers can be taken into consideration). thus here second point for specification arises, - Specification of Linker size (in terms of Mol Wt./Daltons).
Additionally the "biodegradibility rate" of linkers can become another specification point to be focused upon as this need to be addressed in accordance to the delivery of the drug cargo to the location where parasites harbor.
It can be a very useful data pool if anyone extends his visions regarding this analogy. Critics are most welcome too.
Looking into the mortality rate with Malaria, a futuristic corrective and roboust strategy in new drug design is the need of the time.
Thanks Dr Sharma for pouring your excellent ideas to the forum.
best regards
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