What are the ways of determine a cognitive changes in muscarinic acetyl choline receptors activation?

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Alexander V Panov

Please, could you explain your question or problem more clearly?

Agboola James

Yes @Alexander, central cholinergic signaling via muscarinic receptor is implicated in learning and memory. one of the mechanism by which cholinergic signaling influence cognitive has been assumed to be directly cholinergic stimulation of pre- and postsynaptic hippocampus neuronal receptors. muscarinic receptor is one of the kind of acetycholine receptor. My principal target is this receptors by checking for d activities of my bioassays guided isolated compounds on this receptor. I am looking for a ways of determine a cognitive changes in muscarinic acetyl choline receptors activation after administeration of my isolated compound (s). Thanks.