What are the significant differences at molecular levels regarding drugs-induced hepatotoxicity?

17 April 2014 1 6K Report

With concentration on (INH-Rifampicin , Acetaminophen , Alcohol , CCl4 , NSAIDs)

miR-122 or Keratin 18..can you be more specific with the question, then would love to discuss ...

Also depending on the drug there can be changes..drug means the MOA of hepatotoxicity...cholestasis will have different signatures compared to hepatocellular..though mitochondrial tox can be a common feature for both of them...apart from Fas-induced apoptosis i think

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