I am interested in the synthesis of oligosaccharide nanoparticles. In literature Chitosan has been used to synthesize its nanoparticles and conjugated metal nanoparticle. Does amine group has any role in formation of its nano form? I request the experts of this field to guide me/ share the methods used for synthesizing and stabilizing carbohydrate (oligosaccharide) nanoparticle.
You can hydrolyze starch or cellulose (cotton) and get water-soluble oligosaccharides. They will not be nanoparticles, i.e. solid dispersed systems. Hitosan is also a natural substance, but with a large molar mass. Therefore, it is not soluble in water and exists as a dispersion in water. Chitosan (oligosaccharide), for example with MM = 20, 38 kDa, is water soluble. Researchers offer polysaccharide nanoparticles consisting of chitosan (CS) and cyclodextrin (CD) derivatives. For this you need to conduct a complex synthesis. Amino groups are not responsible for imparting nanoform. The nanoform is given by the molar mass of chitosan. Amino groups interact with a proton in an acidic medium and give a positive charge to chitosan nanoparticles.
Hello
Here is a very good paper regaring your query
Article New Generation of Hybrid Poly/Oligosaccharide Nanoparticles ...
You can hydrolyze starch or cellulose (cotton) and get water-soluble oligosaccharides. They will not be nanoparticles, i.e. solid dispersed systems. Hitosan is also a natural substance, but with a large molar mass. Therefore, it is not soluble in water and exists as a dispersion in water. Chitosan (oligosaccharide), for example with MM = 20, 38 kDa, is water soluble. Researchers offer polysaccharide nanoparticles consisting of chitosan (CS) and cyclodextrin (CD) derivatives. For this you need to conduct a complex synthesis. Amino groups are not responsible for imparting nanoform. The nanoform is given by the molar mass of chitosan. Amino groups interact with a proton in an acidic medium and give a positive charge to chitosan nanoparticles.
ِDear researcher
You can use the glucose-based balk natural substance including cellulose and starch to synthesis the nanoparticles by using the up to down synthesis methods. A chitosan based article also attached here:
Article Synthesis and in vitro study of modified chitosan-polycaprol...
Best regards,
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