Earlier to this decade, all the pesticides were a single compound entity. Eventually due to indiscriminate and intensive use of these pesticides and illiteracy of use of pesticides (abamectin, carbofuran, chlorpyrifos, cypermethrin, deltamethrin, dimethoate, fipronil, lambda-cyhalothrin and paraquat etc.) in underdeveloped and developing countries, there is a problem of pesticide resistance due to accumulation of pesticides. Now due to resistance to the pesticides, combinational pesticides of 2, 3 or 4 compound mixtures are in use. This is also failing to reach to the target and hampering the live stocks too. Residues have also been found in rain and ground water and other biota.
Pesticides are economic poisons and at first line of defence though its toxicity is less but cumulative non targeted and residual toxicity is more.
Phenylpyrazole chemical family, OP compounds and chlorinated hydrocarbons one way the other are toxic. Some of them are neurotoxic (GABA blocker), inhibitors of neurotransmitters, reproductive and developmental defects in humans, immunological abnormalities and haemopoietic cancers and so on. These differences emphasize the difficulty in making one-fits-all decisions with respect to pesticide use.
Vasant Eknath Narke , "Earlier to this decade, all the pesticides were a single compound entity." This is not true. In 1979 I started as an ecotoxicologist specialized in pesticides in the tropics, which were always identified by name and formulation. In my work as well as in the literature. I had my PhD on the environmental effects of deltamethrin in 1989. I never had to explain that the compound was 'a pesticide'.