What are the most novel innovative treatments or novel targeted therapies in RR DLBCL (clinical trials, immuno-oncology, rituximab, stem cell transplantation, precision medicin, omics)? The best review I have found so far is attached below.
The potential options are:
1. Brentuximab+ salvage chemo for CD30+ RR DLBCL
2. Revlimid or ibrutinib + salvage chemo for ABC type RRDLBCL
3. CD19 CART based therapy
4. Blinatumomab+ salvage chemo
5. SGN 19 ADC + salvage chemo
remeber none of the above choices are FDA approved options at current time. These all are in clinical trials. Thank you
Mehrdad,
Congratulation to your promising results in Zuma-1:
http://ir.kitepharma.com/releasedetail.cfm?ReleaseID=1014817
Really hopeful for these patients!
durvalumab or durvalumab + (tremelimumab or AZD9150) - Phase 1: PD-L1 mAb or PD-L1 mab + (CTLA-4 mAb or STAT3 inhibitor)
https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/view?cdrid=779832&version=HealthProfessional&protocolsearchid=6195607
http://ascopubs.org/doi/pdf/10.1200/JCO.2015.65.9789
https://clinicaltrials.gov/ct2/show/NCT03015896
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322257/pdf/zlj540.pdf
http://biovica.com/biovica-participates-in-a-european-research-project-for-developing-a-new-cancer-drug/
Promising study with SMAC mimetics: https://www.researchgate.net/publication/301201737_Targeting_Non-proteolytic_Protein_Ubiquitination_for_the_Treatment_of_Diffuse_Large_B_Cell_Lymphoma
Article Targeting Non-proteolytic Protein Ubiquitination for the Tre...
New treatment for RR DLBCL presented (polatuzumab vedotin plus bendamustine and MabThera/Rituxan (BR) ): https://www.otcmarkets.com/ajax/showNewsReleaseDocumentById.pdf?id=28695
A comparison of two recent treatments of DLBCL using anti-CD19 CAR-T therapy:
https://endpts.com/ash17-how-does-novartis-kymriah-dlbcl-data-stack-up-heading-straight-to-a-car-t-showdown-with-gilead/
https://www.researchgate.net/publication/280602026_CAR_T-Cell_Therapy_The_Role_of_Physical_Barriers_and_Immunosuppression_in_Lymphoma?_iepl%5BgeneralViewId%5D=2201eiBYDABHp7KFuwrxTarRI0CMCzPj00rP&_iepl%5Bcontexts%5D%5B0%5D=searchReact&_iepl%5BviewId%5D=MfxH9SZOJ1JucVG1K848JDrQkgg3c9G96bwo&_iepl%5BsearchType%5D=publication&_iepl%5Bdata%5D%5BcountMoreThan20%5D=1&_iepl%5Bdata%5D%5BinteractedWithPosition20plus%5D=1&_iepl%5Bdata%5D%5BwithoutEnrichment%5D=1&_iepl%5Bposition%5D=36&_iepl%5BrgKey%5D=PB%3A280602026&_iepl%5BtargetEntityId%5D=PB%3A280602026&_iepl%5BinteractionType%5D=publicationTitle
Very promising and interesting. I recommend lymphoma patients to start Vitamin D supplementation during R-CHOP treatment: Article Vitamin D deficiency and supplementation in patients with ag...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2%3A1288945&dswid=8905
https://medicalxpress.com/news/2019-06-immunotherapy-hdac-inhibition-anti-cancer-besties.html
I have given such a patient in 2013 a large amount of vitamin D in several doses. He's probably good, after CHOP-R, to this day.
VITAMIN D is the answer !
I have given such a patient in 2013 a large amount of vitamin D in several doses. He's probably good, after CHOP-R, to this day.
Adrian, I also recommended Vitamin D to a patient during and after CHOP-R treatment, and no relapse so far - after two years.
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