I'm looking for references on the minimal requirements for dimerization of the FIV genome. From what I understand, the FIV genome is composed of 2 RNA constructs that are dimerized before being packaged in the capsid. I want to know if both constructs contain essential elements for FIV replication. Or is one construct sufficient, while the other might be replaced with a therapeutic cargo?

Ultimately, I'm trying to find out how much of the FIV genome is available for incorporating heterologous genetic material.

Any Direction Welcome.