Characterization of drug loaded nano emulsions using photon correlation microscope with zeta sizer.
Of course, the large PDI means that the size distribution is not narrow, but that piece of information is not necessarily bad news.
- The large value does not imply that your nanoemulsion is a bad product.
- If the size distribution is stable in time and there are no reasons to require a narrow size distribution, then the result has no particular implications.
- In general, I feel that people worry too much about broad size distributions.
Droplet size in nanoemilsions ranges between 20-500nm. The polydispersity index of 1 means the emulsion is highly polydisperse. In layman's term droplet sizes are highly varied. Because of such variations the most common phenomenon that occurs in nanoemilsions is Oswald Ripening meaning smaller particles submit themselves to the bigger ones and start growing bigger and eventually cause destabilization of nanoemilsions. As you are aware, smaller particles resist gravity separation, flocculation, coalescence, and creaming due to Brownian motion. Lower PDI signifies higher stability.
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