A large data gap is the matching of multipathway exposure with body burden: Human behavior differences account for great exposure differences between nearly all chemicals that enter the body via many pathways. As far as pesticide specific exposures, I believe the metabolism differences due to sex and age is significant and not sufficiently studied in humans. There are marvelous exposure studies on rams, dams, rats, mice, monkeys and insects –most showing great differences in uptake and elimination rates. High dose human studies have been conducted mostly on men, with some exception to the few textiles and farm studies that involved women and children. Low dose studies have involved the general population, with biomarkers, but little understanding with the pathway of exposure. The limited Biomarker and exposure studies suggest that children and women take up and eliminate pesticides (and SVOCs) faster and children receive a higher body burden than just their small bodies would explain.
The gap areas that i identified and need to be addressed is lack of metaanalytic studies vis a vis multipesticide exposures and secondly the lack of genome & environment wide association studies.
In the social context; the problem of pesticides, whether insecticides or for preservation of grain, dates or other agricultural products need a community based interventions with health education programmes, community sensitization and mobilization and outreach through health education programs on how to deal with pesticides, the amount to be in the spraying, how to save /destroy its containers, safe handling, signs and symptoms in case of contamination……
The gaps in the pesticide research are as given here under:
1 biodegradability under different environments
2 harmfulness to children, adults and aged individuals
3 Effect of multiple pesticides on human population 4half life time in the soil and bio accumulation
5 effect on cattle and poultry animals
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