What are the % of sex hormone bind to SHBG and albumin ,
and what affected these %?
Basically, Sex hormone-binding globulin (SHBG) are extremely important vehicular blood proteins responsible for transporting sex steroids in the plasma. They are produced in the liver under the influence of Estrogen, and they control and regulate the accessibility of sex hormones to target organs. It means that SHBG controls the amount of free sex hormones available to the body. In turn, SHBG levels is regulated by sex hormones. It is increased by estrogen and decreased by testosterone. Estrogen, DHT, and Testosterone are strongly bound to SHBG but weakly to Albumin. Progesterone binds to Cortisol binding globulin and Albumin. The ratio of SHBG to Albumin at any given period is not fixed. It is altered by age, sex, obesity, liver disease, hyperthyroidism, estrogen-containing preparations, hyperinsulinaemia, acromegaly, glucocorticoids and pregnancy.
The sex hormone high Bind with globulin compare with albomine for to transporting through blood stream. These protein plasma are prodused by liver.
