Name at least two or three pharmacological actions of marijuana but which are poorly studied or neglected for clinical use.
Dear Dr Linda Klumpers,
My question stems from a systematic review that we are elaborating and I wanted to hear the opinion of other researchers. I think ResearchGate is a great environment for these discussions. Do not you think?
Best
Effect of cannabinoids on liver function / lipid metabolism, and cannabinoid influence of neuroendocrine regulation of hormone secretion (which might be gender dependent).
In addition to what was said by Dr Michel G Fortuna marijuana produces its effects by changing the rate of what is already going on in the brain. In this case, the active ingredient delta-9-THC substitutes for your own natural endocannabinoids and mimics their effects. It activates the same chemical processes the brain employs to modulate thoughts, emotions and experiences. These specific neurotransmitters, used in a targeted and judicious way, help us sort the relentless stream of inputs and flag the ones that should stand out from the torrent of neural activity coding stray thoughts, urges and experience. By flooding the entire brain, as opposed to select synapses, marijuana can make everything, including the most boring activities, take on a sparkling transcendence.
Dr. Quintans-Júnior, I am wondering where your question originates from.
It elevates the heartbeat in an greater extend (may creates wrong effect on heart patients) and over dose may cause continuous shivering or locomotor disabilities.
Dear Dr Linda Klumpers,
My question stems from a systematic review that we are elaborating and I wanted to hear the opinion of other researchers. I think ResearchGate is a great environment for these discussions. Do not you think?
Best
The "Entourage-Effect" (interdependence of Cannabinoids and Terpenes for increased pharmacological effects) is possibly the most important neglected aspect in clinical studies involving cannabis. Most clinical studies are using cannabinoid isolates.
Furthermore the effect of different cannabis strains (with different cannabinoid and terpene profiles) and their effectiveness for different conditions is also something that I have not yet seen in clinical studies.
The same goes for Cannabis Extracts where different solvents and types of processing play a huge role in what part of the spectrum of active compounds get extracted. This can lead to major differences in the impact of cannabis medication.
Have a look at: "Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol" and "Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects" for more information.
https://file.scirp.org/pdf/PP_2015021016351567.pdf
Article Taming THC: Potential cannabis synergy and phytocannabinoid-...
Michal G Fortuna Sir, is it any report regarding gender dependent study, Kindly provide the link. Curious to know.
Regards
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