Its depends up on that what types of mushrooms you cultivated. its batter to used traditional substrate for oyster and milky cultivation because these mushroom need high lignin content for their feed and that may not be higher in case of organic wastage but you may use organic wastage for button mushroom where we already use compost for cultivation and this may improve the nutrient capacity of compost which direct improve yield and bio efficacy of mushroom

All mushroom cultivation uses some form of organic waste as a substrate. It all depends on the species that you are cultivating. Some mushrooms require near sterile substrates while others thrive on a rich community of bacteria and other fungi. These differences produce a selective media that favors the growth of the particular species of interest. For some mushrooms supplements high in fatty acids or protein can significantly boost yield. Cost is an important factor and organic waste is typically very cheap. Additionally there is a tremendous body of literature on how to grow each species on particular substrate so you do not have to re-invent the wheel to cultivate mushrooms. Lab media, for example, can be used to produce mushrooms but at a huge cost.