What are some common off-label uses of magnesium sulfate in clinical practice?

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Abdul Razzaque Nohri

Off label use of MGSO4 as per MEDSCAPE is as under:

Preterm Labor (Off-label)

Used as a tocolytic to stop preterm labor

Loading dose: 4-6 g IV over 20 minutes; maintenance: 2-4 g/hr IV for 12-24 hours as tolerated after contractions cease

Do not exceed 5-7 days of continuous treatment; longer treatment duration may lead to hypocalcemia in developing fetus resulting in neonates with skeletal abnormalities related to osteopenia

Samuel Jirom Welday

Off-label uses include polymorphic VT (without known hypomagnesemia), and moderate to severe asthma exacerbations.