I need research papers and insights from fellow ResearchGate members on the molecular effects of Hibiscus sabdariffa on stress-exposed cells, tissues, organs, and systems of the body
Start with a literature search, it will give you a much more complete list than asking folks.
Are you interested in tissue culture, model animals, humans, etc?
The protective effects of Hibiscus sabdariffa are mediated through several key molecular pathways:
- Nrf2/ARE Pathway: Activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway leads to the transcription of antioxidant response element (ARE)-regulated genes, enhancing cellular defenses.
- MAPK Pathway: Modulation of mitogen-activated protein kinase (MAPK) signaling reduces inflammation and apoptosis.
- PI3K/Akt Pathway: Activation of this pathway promotes cell survival and inhibits apoptosis.
- AMPK Pathway: Stimulation of AMP-activated protein kinase (AMPK) improves energy metabolism and reduces lipogenesis.
Yes, a protein can potentially be expressed in a mouse with a knocked-out gene, depending on the experimental design and the nature of the genetic modification.A study might use a conditional knockout mouse where the gene is deleted in the liver but remains functional in the brain. In this case, the protein would still be expressed in the brain but not in the liver.
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