Flatfish metamorphosis, including the eye migration is essentially a thyroid hormone regulated process (Power et al 2008) which may even be independent of hypothalamic control (Campinho et al 2015).

During the metamorphic process, it's mostly the front part of the cranium which becomes truly asymmetric, when changes in skeletal and muscle morphology force the migration of the eye (see e.g. Saele et al 2006).

Article Twisted story of eye migration in flatfish

Article The Molecular and Endocrine Basis of Flatfish Metamorphosis

Article Flatfish metamorphosis: A hypothalamic independent process?

Hi

Many thanks for answering my question about the migration of the eye of the flatfish, but can let me know why in some species the eye migrates to the left and in other species migrates to the right?

I would be much grateful if you let me know the answer for this question.

Regards

Laith A. Jawad

Dear Laith,

I don't have an answer to the question of left-sided vs right-sided flatfish species, and am not sure if anyone has cracked this question. However, while the sidedness is species-specific, e.g. the Atlantic halibut is a right-sided species, a few left-sided individuals can always be found within the population. This suggests that there are dominant/recessive genes determining this. 

Dear Laith

I do not have any clue to your question about  the left or right side eye migration in faltfishes. Sole as halibut is a right side species, but some times we find some left sided individuals. So may be there is a genetic role in this process besides the endocrine one

Dear Naria

many thanks for your reply and the answer.

I am interested in the halibut with eyes on the left. This is a case should be reported. Are you still having the specimen/s?

We can cooperate.

regards

Laith

Dear Laith

 We work on sole not in halibut, but so far we  do not have have samples of left sided sole.

Regards

 Maria

Dear Maria

since you are working in Aquaculture, I wonder whether you are interested to to cooperate with me in a project to compare the wild and aquaculture specimens. Also, we can study the effect of aquaculture on fish stock in the wild. for this study we can use the sole fish species you are studying. In this project we shall examine some morphological characters of the fish in addition to the morphology of the otolith and scales.

I am looking forward to hearing from you.

Regards

laith