During development (embryonic stage) white matter in the cerebral develops fast and is during the perinatal stage. Within two decades the maturing process begins the aging process. The lifespan of the participant/sufferer/cadaver is essential in understanding size abnormalities within the different dimensional aspects in neurology. This comes from pathological studies, ‘neuroimaging’ using aspects like the fMRI. Past research has been limited to macrostructures in imaging and measurements. The beginning to your research can hypothetically be synapse flow, where alternating proteins and lipid layers amount to structuring aspects. The space outside the myelin sheath is developed from cholesterol, galactocerbroside, phosphatidylethanolamine, phosphatidylcholine, sphingomyelin, phosphatidylserine, sulfatide, phosphatidylinositol, atty acids, and proteins (Wozniak, & Lim, 2006).

References

Wozniak, J. R., & Lim, K. O. (2006). Advances in white matter imaging: A review of in vivo magnetic resonance methodologies and their applicability to the study of development and aging. Neuroscience and Biobehavioral Reviews, 30(6), 762–774. http://doi.org/10.1016/j.neubiorev.2006.06.003

Thank you Michael

Pathology associated blindness(congenital) and Alzheimer's disease in early stage to alter CC

Thickened corpus callosum may be associated with abnormal bundles, suggesting underlying axonal guidance abnormality.A thick corpus callosum also has been linked to enlarged white matter and macrocephaly in patients with neurofibromatosis and has also been described in patients with the macrocephaly–capillary malformation syndrome. Isolated cases also noted without any associated anomaly or symptoms.

Dear Dr. Tomar,

Thank you, for your reply