In studying sleep quality (using PSQI) in patients with systemic lupus erythematosus, we found an inverse correlation between serum vitamin D level and sleep disturbance. Correlation remained significant after controlling for age, BMI, physical activity, disease characteristics (duration, activity) and receiving prednisolone.
Is it a cause and effect relationship? And what are the possible mechanisms?
There was another study that indicated a relationship between vitamin D deficiency and sleep disturbances, which I came acrossed recently.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501666/
McCarty DE; Reddy A; Keigley Q; Kim PY; Marino AA. Vitamin D, race, and excessive daytime sleepiness. J Clin Sleep Med 2012;8(6):693-697.
The authors found an inverse correlation of vitamin D and sleep disturbance and questioned which condition triggers the other condition. This assumes that there is a causal relationship, but I don't think that this mechanism has been fully examined.
The same authors have a more recent publication, but I have only seen the abstract. It might have more information for you.
Sleep Med Rev. 2013 Sep 25. pii: S1087-0792(13)00073-7. doi: 10.1016/j.smrv.2013.07.001. [Epub ahead of print]
The link between vitamin D metabolism and sleep medicine.
McCarty DE, Chesson AL Jr, Jain SK, Marino AA.
I think the topic is ripe for another study!
Julie
Dear Julie,
You may would like to have a look at our study results:
http://www.ncbi.nlm.nih.gov/pubmed/24731962
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