Uterine cancer in women?

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Dmitry Zinovkin

For endometrioid adenocarcinoma (EA) the irregularities in the DNA mismatch repair genes in the context of high levels of estrogen play an important role in the EA development. Women in premenopausal period with disorders of the MMR genes take a high risk for EA, In contrast to young women with high levels of estrogen and sufficient level of products of MMR genes, or elderly women with low estrogen levels and atrophic endometrium with low proliferative activity.

Khalid El Bairi

http://www.ncbi.nlm.nih.gov/pubmed/?term=Uterine+cancer+in+women