I've been looking at the reaction of aryl amines with sodium cyanate in acetic acid for the generation of ureas. Does anyone know whether this reaction scheme can be applied to alkyl amines?
Andrei Rogoza
Its very doubtful. Nucleophile ( R-NH2) will be blocked because the aliphatic amines are more basic than aromatic.
Apparently for laboratory purposes it is more suitable reaction of amines with trimethylsilyl isocyanate, followed by methanolysis. Thus will get a very clean products without triazines as impurities.
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