There are many many papers using the monoketal. Here are a few.

Bill Berkowitz

Dimethoxy-acetaldehyde is commercially available:

Sigma Aldrich 479047 60 wt. % in H2O

Glyoxal 1,1-dimethyl acetal solution

IUPAC: dimethoxyacetaldehyde

Alfa Aesar Supplier Name: Alfa Aesar A Johnson Matthey Company, Catalog Publication Date: 29 Oct 2012 Order Number: L18490 Quantity: N/A 51673-84-8 Glyoxal dimethyl acetal, 60% aq. soln.

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Chem. Commun., 2012, 48, 7790–7792

Organocatalyzed Michael–Henry reactions: enantioselective synthesis of

cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate

Bor-Cherng Hong; Po-Yuan Chen; Prakash Kotame; Pei-Ying Lu,; Gene-Hsiang Lee; Ju-Hsiou Liaoa

(MeO)2CHO used to make HOCH2CH=CH-CHO

Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4

receptor agonist: Clinical compound TD-2749

Daniel D. Long; Scott R. Armstrong; et al

Bioorganic & Medicinal Chemistry Letters 22 (2012) 4849–4853

The monoketal is used to convert R2NH to R2NCH2CH(OH)2 via reductive amination

Chiral Biscarboline N,N’-Dioxide Derivatives: Highly Enantioselective Addition of Allyltrichlorosilane to Aldehydes

Bing Bai; Lan Shen; Jie Ren; Hua Jie Zhua

Adv. Synth. Catal. 2012, 354, 354 -358

A multiply convergent platform for the synthesis of trioxacarcins

Jakub Švenda, Nicholas Hill, and Andrew G. Myers

PNAS ∣ April 26, 2011 ∣ vol. 108 ∣ no. 17 ∣ 6709–6714

as shown in Fig. 3 Left, beginning with a highly diastereoselective auxiliary-controlled Baylis–Hillman reaction between the Oppolzer sultam-derived acrylimide 9 (1 eq) and anhydrous 2,2-dimethoxyacetaldehyde (3.0 eq) using 1,4-diazabicyclo[2.2.2]octane (DABCO, 0.3 eq) as catalyst in dichloromethane at 23 °C (16 h). The product of the reaction had incorporated two molecules of 2,2-dimethoxyacetaldehyde, and had expelled the sultam auxiliary by internal lactonization, as anticipated based on precedent (27)

Direct Entry to Erythronolides via a Cyclic Bis[Allene]

Kai Liu; Hiyun Kim; Partha Ghosh; Novruz G. Akhmedov; Lawrence J. Williams

J. Am. Chem. Soc. 2011, 133, 14968–1497

Addition of the enolate derived from oxazolidinone 1 to commercially available dimethoxyacetaldehyde afforded the expected aldol product as a single isomer (2,90%).