If there are two surgeons in two different institutions and both are mastered in two different surgical techniques, can we compare the outcome of their patients to understand the value of each intervention? Let me also put this; when I mean "mastered" learning curve for the intervention is suggested as 100 cases and each had done that intervention for more than 500. I am asking this question as we have a study like this and it has been rejected for this limitation. However, I have encountered similar studies in the literature and would like to know how to respond or how to make a revision in our study.