As far as we know the neural basis of emotional processing (amgidala, anterior insula) keep a kind of lineal stimulus dependence that is assumed to go mostly throug conscious regulation but it also go nonconsciuos . Clinically becomes relevant while working with chronic pain patients, in what degree thermosensors role (TRPV1 and 4) may participate to modulate nociception modulation increasing it or shaping an analgesic emotioanl mediated effect (anterior insula contribution)

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