It's just that the immune system is incredibly complicated, and it's very difficult to focus. I'd like to hear about how you all do this. O,' the other thing is that I also focus on what cancer patients and their families are going through -a little side effect of 30+ years of cancer research. It's a psychology aspect of cancer most people don't think about, but in reality affects us all.
Hi, I am working in the same field and need some knowlede abut how immune cells distribute over the tumor site. I mean where they are more and where less. To clarify, the population of tumor cells is more near the boundary or at the center?
it is nice of u to give me some hints.
Cheers,
My present focus is on the immunobiology of Tregs and Th17 cells as far as cancer is concerned. With that being said, here are two references about DC localization in renal cell carcinoma and how it relates to T cell regulation. Let me know if this helps:
Oldham KA, Parsonage G, Bhatt RI, Wallace DM, Deshmukh N, Chaudhri S, Adams DH, Lee SP (2012) T lymphocyte recruitment into renal cell carcinoma tissue: a role for chemokine receptors CXCR3, CXCR6, CCR5, and CCR6. Eur Urol 61: 385-395.
Bayry J, Triebel F, Kaveri SV, Tough DF (2007) Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells. J Immunol 178: 4184-4193.
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