working on the different cell line I don't now there is different between liposome and niosmoe in toxicity?
how can I decrease the toxicity of them?
Dear Mahmood,
Niosomes are vesicular systems which are similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. However, they are less toxic than liposomes and improve the therapeutic index of drugs by restricting their actions to target cells.
For more on Niosomes & Liposomes, please see the following link:
http://www.slideshare.net/swethaaitha/liposomes-and-niosomes-15259272
Hoping this will be helpful,
Rafik
Dear Mahmood Barani
Liposomes are mainly composed of phospholipids, amphiphilic molecules that have a hydrophilic head and two apolar hydrophobic chains.
Niosomes are non-ionic surfactant based unilamellar or multilamellar bilayer vesicles up on hydration of non ionic surfactants with or without incorporation cholesterol .
Liposome is more toxic than niosome based on the RBC potassium release assay and intravenous dosing in uninfected mice given a single 50 mg/kg dose (80% mortality for Liposome vs. 0% for niosome).
Thank you
Marius
The in vivo toxicity of liposomes depends on their composition, with positively charged lipids, such as those used in DNA transfection reagents, being far more toxic than neutral lipids. In my experience, neutral unilamellar liposomes consisting of phosphatidylcholine and cholesterol are very well-tolerated at high doses in mice and rats. I have not worked with niosomes.
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