The relationship between COVID-19 & blood clots
One of the clinical studies published in the Radiological Society of North America RSNA journals confirmed that one of the reasons that leads to the deterioration of the health condition of COVID- 19 patients is the occurrence of blood clots in the arteries, including the leg artery..
These clots occur due to several factors, the most important of which is damage to the arterial layers, or because of the increased tendency of blood to clot, or by the reaction of the immune system to the virus
Resnt studies identified association between ABO blood groups and COVID-19.It was found there is a beneficial association between Rh- negative blood groups and both infection status and death.
Abdulridha Taha Sarhan. Because the virus of COVID-19 was considered from WHO as novel, therefore the studies and results are many and continue.
Dear all, blood clots is found to have the highest percentage of death responsibility. Using anti-coagullants with covid-19 patients reduced both mortality and intensive care cases. My Regards
Clots occur due to several factors, the most important of which is damage to the arterial layers, or because of the increased tendency of blood to clot, or by the reaction of the immune system to the virus
Experts are still learning exactly how COVID-19 affects the body. One worrisome symptom that has emerged is blood clots.
“We’re seeing a higher rate of blood clots in patients hospitalized with COVID-19,” says pulmonologist Wayne Tsuang, MD. “But it’s not clear yet how common clots are in people with mild symptoms who are at home.”
Blood clots are associated with serious complications, such as stroke. Scientists are scrambling to learn more about why the clots are occurring in coronavirus patients and who is most vulnerable. Here’s what we know so far.
July 20, 2020 — COVID-19 is associated with life-threatening blood clots in the arteries of the legs, according to a study published in Radiology. Researchers said COVID-19 patients with symptoms of inadequate blood supply to the lower extremities tend to have larger clots and a significantly higher rate of amputation and death than uninfected people with the same condition.
COVID-19's association with blood clots in the pulmonary arteries is well-established. Less is known about the virus' connection to lower extremity arterial thrombosis, a condition characterized by blood clots in the arteries that impede the flow of oxygenated blood to the lower extremities.
During the peak of the COVID-19 pandemic in New York City, radiologists at the city's Montefiore Medical Center observed an increase in patients testing positive for lower extremity arterial thrombosis on CT angiography exams. The patients had arrived at hospitals with coldness, pain or discoloration of their legs. Frequently these symptoms of leg ischemia, a condition in which blood flow to the lower extremities is restricted, were accompanied by respiratory distress, cough, fever and altered mental status.
The alarming trend prompted the researchers to look more closely at a possible connection between COVID-19 and lower extremity arterial thrombosis and whether people with the virus had a worse prognosis.
In March and April 2020, they identified 16 COVID-19-positive patients, average age 70, who underwent CT angiography of the lower extremities for symptoms of leg ischemia. These patients were compared with 32 COVID-19-negative patients, average age 71, who underwent CT angiography with similar symptoms in previous years and who were well matched with COVID-19 cohort for demographic and clinical characteristics.
All patients with COVID-19 infection undergoing lower extremity CT angiography had at least one clot in the leg, compared with only 69% of controls. The clots in the COVID-19 patients were significantly larger and affected arteries higher up in the leg with greater frequency than those in controls. Death or limb amputation was more common in the COVID-19 patients.
"We found that arterial thrombosis associated with COVID-19 infection was characterized by dire outcomes, namely strikingly increased rates of amputation and death, which in our series were 25% and 38%, respectively," said study lead author Inessa A. Goldman, M.D., a radiologist at Montefiore and assistant professor at Albert Einstein College of Medicine in New York City. "For comparison, the rate of both amputation and death was only 3% among controls. It is unclear whether the patients' concurrent COVID-19-related pneumonia, the virulence of the COVID-19-related clotting disorder or delayed initial arrival to the hospital contributed to these outcomes."
COVID-19 patients presenting with symptoms of leg ischemia only were more likely to avoid amputation or death than patients who had symptoms of ischemia and systemic symptoms including cough, respiratory distress or failure, hypoxia, fever, or altered mental status.
Dear Nasser Said Gomaa Abdelrasheed , thank you for this scientific information about COVID-19
In clinical practice, so far I have seen suspected cases of Covid-19 who visit the imaging department for other procedures such as a Neck ultrasound, with clots in the internal jugular veins, the upper limb veins, IVC and even extending to the distal lower limb veins. I'm yet to find the association of these clots with this novel virus.
A recent study found that in a set of 400 hospitalized COVID-19 patients, the overall rate of clotting was 10 percent and the rate of confirmed venous thromboembolism, mainly deep vein thrombosis, was 5 percent.
.https://news.weill.cornell.edu/news/2020/07/what-is-known-about-covid-19-and-abnormal-blood-clotting
In addition to the well-known breathing problems, blood clots are a significant danger for COVID-19 patients. Clots are ...
https://www.webmd.com/lung/news/20200424/blood-clots-are-another-dangerous-covid-19-mystery
Changes in blood platelets triggered by COVID-19 could contribute to the onset of heart attacks, strokes, and other serious ...
https://www.sciencedaily.com/releases/2020/06/200630125129.htm
Among the many mysteries is exactly how SARS-CoV-2, which is the novel coronavirus that causes COVID-19, triggers the formation of blood clots that can lead to strokes and other life-threatening complications, even in younger people.
https://directorsblog.nih.gov/2020/06/11/searching-for-ways-to-prevent-life-threatening-blood-clots-in-covid-19/
Blood coagulation is occurred due to various disorders like stroke, we are observing the same incident for C-19.
Dear Tryness RUFARO Katsaura . Clots may be occur due to several factors, the most important of which is damage to the arterial layers, or because of the increased tendency of blood to clot, or by the reaction of the immune system to the virus
Dear Chinaza Godswill Awuchi , some researchers said COVID-19 patients with symptoms of inadequate blood supply to the lower extremities tend to have larger clots and a significantly higher rate of amputation and death,
Experts are still learning exactly how COVID-19 affects the body. One worrisome symptom that has emerged is blood clots.
https://health.clevelandclinic.org/should-you-be-worried-about-blood-clots-with-covid-19/
There are reports that clots are forming in people with COVID-19 who are at home and mobile — not just those lying flat in a hospital bed. But it’s not clear yet how common they are.
https://health.clevelandclinic.org/should-you-be-worried-about-blood-clots-with-covid-19/
Yes; the changes in blood platelets triggered by COVID-19 could contribute to the onset of heart attacks, strokes, and other serious. That may be.
Coagulation of RBC - a majour symptomatic Covid19 problem - https://www.medicalnewstoday.com/articles/covid-19-possible-mechanism-for-blood-clotting-identified
The clots of blood by COVID 19 causing the death in some patients
"Thromboembolic complications of COVID-19: the combined effect of a pro-coagulant pattern and an endothelial thrombo-inflammatory syndrome"
This is our article recently published in Clinical Radiology, official journal of the Royal College of Radiologists.
It is freely available at Article Thromboembolic complications of COVID-19: the combined effec...
I hope it's useful!
https://www.google.com/amp/s/news.umiamihealth.org/en/the-link-between-covid-19-and-dangerous-blood-clots/amp/
Yes, there is a relationship between high blood clotting and the formation of blood clots when infected with "Covid-19". That after the entry of the new coronavirus into the body, the protein responsible for stimulating the part of the immune system responsible for blood clotting activates.
A recent study found that in a set of 400 hospitalized COVID-19 patients, the overall rate of clotting was 10 percent and the rate of confirmed venous thromboembolism, mainly deep vein thrombosis, was 5 percent.
Yes disseminated intravascular coagulation is a pathophysiological feature of SARS-cov2 infections.
Dear Prof. Al-Zaidi!
Yes, but fortunately new research is emerging all the time:
1) Vallabh Janardhan et al. (2020). "COVID‐19 as a Blood Clotting Disorder Masquerading as a Respiratory Illness: A Cerebrovascular Perspective and Therapeutic Implications for Stroke Thrombectomy" Journal of Neuroimaging 10 August 2020, Open Access © 2020 American Society of Neuroimaging,
Available at:Article COVID‐19 as a Blood Clotting Disorder Masquerading as a Resp...
2) Swati Srivastava et al. (2020). "COVID-19 infection and thrombosis" Clinica Chimica Acta Volume 510, November 2020, Open Access © 2020 Elsevier B.V. Available at:
Article COVID-19 infection and thrombosis
3) Oscar Eriksson et al. (2020). "Mannose-Binding Lectin is Associated with Thrombosis and Coagulopathy in Critically Ill COVID-19 Patients" © 2020 Georg Thieme Verlag KG in Uppsala University (2020). "Possible blood-clotting mechanism in COVID-19 found" 2 September 2020, Copyright 2020 ScienceDaily Available at:
Article Mannose-Binding Lectin is Associated with Thrombosis and Coa...
Yours sincerely, Bulcsu Szekely
Yes, intravascular disseminated flocculation is an underlying the pathogenesis characteristic of SARS-cov2 outbreaks.
yes there is a big correlation between covid 19 and incidence of clots especially PE and DVT
Now. Because the correlation between covid 19 and incidence of clots some peoples in the world avoid take the covid Vaccine.
Dear Dr Al Zaidi, Thank you for sharing this excellent discussion.
Too little percentage..
With kind regards..
Dear Jawad ;
Several hypotheses could explain the formation of the blood clots. In blood vessels, the cells forming their inner lining, the endothelium, have on their surface the ACE2 protein, the same one that allows the coronavirus to enter the lung cells. When the virus travels through the bloodstream and kills the endothelium cells, it will expose the basement membrane just below, which platelets and other clotting factors can react with to prevent blood loss. The more this endothelium is exposed, the more clotting.
Another hypothesis involves the immune system itself. "Cell death will cause inflammation. Several inflammatory factors also play a role in blood clotting. In addition, certain white blood cells called neutrophils can produce a very sticky substance called "Net" (neutrophil extracellular trap), which serves to trap pathogens, but which can also promote clotting. These are normal reactions, but the scale at which they are found in this disease is unusual.
With my best regards
Dear Doufnoune RACHIDA Rachida ,many thank to you for mansion Several hypotheses could explain the formation of the blood clots and relation it with COVID-19.
COVID-19 can make blood cells more likely to clump up and form clots. While large clots can cause heart attacks and strokes, much of the heart damage caused by COVID-19 is believed to stem from very small clots that block tiny blood vessels (capillaries) in the heart muscle.
https://www.mayoclinic.org/coronavirus-long-term-effects/art-20490351