Tamoxifen cre-LoxP system?

17 May 2019 0 7K Report

We are delivering 3 mg tamoxifen per animal once daily for 5 days in the week before our experiments begin. We are now running an experiment where we need tamoxifen available in the animals for 14-28 days, but it has been shown that tamoxifen is only available in the brain for 8 days after a similar dosing run. Do you have any insight in a long term dosing interval to keep tamoxifen available through our experiment in the brain?

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