As a rule, a systematic review of case reports is carried out when only limited (retrospective) reports are available, e.g. when rare or single cases are involved and prospective studies on these are not feasible, e.g. due to the rarity of the reported events (example: orphan diseases).
The question for systematic reviews of case reports must be clearly defined. The parameters suitable and necessary to answer this question must be considered as selection criteria. It is helpful if standard parameters are also recorded as selection criteria, because this makes it possible to describe the "population" of the selected cases (demographic data, etc.).
The analysis depends on the research question and is usually only descriptive.