I am running a Steglich Esterification with EDC/DMAP in CH2Cl2 on a with the carboxylic acid being a potassium salt that is p-sulfonated. Will the sulfonate group be effected by this reaction? I plan to extract by washing the reaction with brine solution to remove excess EDC/DMAP - does this seem plausible? I do not want to acidify the reaction.
Hello,
From my own experience with steglich esterification, i am using washing with HCl 1N to remove DMAP and NaHCO3 to remove unreacted carboxylic acid.
Dear Alexandra Dillon
Follows the washing procedure as :
Brine solution(volume depend on your sample) => 1M HCl solution(volume depend on your sample) => 5 % NaOH solution (volume depend on your sample) => Distilled Water => finally obtained product => dehydrate with MgSO4 and collect your sample for further characterization.
This process of purification worked very well for my many samples.
Best regards,
Bilal ul amin
Dear A. Dillon,
1N HCl is more suitable to remove DMAP as suggested by G. Degotte and B. U. Amin.
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