I have looking for the data on stability of Curcumin in water. Although, many studies show pH dependent stability of Curcumin, but i couldn't get any which shows stability in water. Specially how long it's stable in water as emulsion form. Can anybody please help me.
Thanks in advance.
Dear Mohammad,
The following link contains a recent kinetic study on curcumin in water at different pHs and in combination with organic solvents. Curcumin have should a first order kinetics when was studied in its free form:
AAPS J. 2016 May;18(3):777-87. doi: 10.1208/s12248-015-9863-0. Epub 2016 Apr 1.
A Kinetic Degradation Study of Curcumin in Its Free Form and Loaded in Polymeric Micelles.
Naksuriya O1,2, van Steenbergen MJ2, Torano JS3, Okonogi S4, Hennink WE5.
Author information
Abstract
Curcumin, a phenolic compound, possesses many pharmacological activities and is under clinical evaluation to treat different diseases. However, conflicting data about its stability have been reported. In this study, the kinetic degradation of curcumin from a natural curcuminoid mixture under various conditions (pH, temperature, and dielectric constant of the medium) was investigated. Moreover, the degradation of pure curcumin at some selected conditions was also determined. To fully solubilize curcumin and to prevent precipitation of curcumin that occurs when low concentrations of co-solvent are present, a 50:50 (v/v) aqueous buffer/methanol mixture was used as standard medium to study its degradation kinetics. The results showed that degradation of curcumin both as pure compound and present in the curcuminoid mixture followed first order kinetic reaction. It was further shown that an increasing pH, temperature, and dielectric constant of the medium resulted in an increase in the degradation rate. Curcumin showed rapid degradation due to autoxidation in aqueous buffer pH = 8.0 with a rate constant of 280 × 10(-3) h(-1), corresponding with a half-life (t1/2) of 2.5 h. Dioxygenated bicyclopentadione was identified as the final degradation product. Importantly, curcumin loaded as curcuminoid mixture in ω-methoxy poly (ethylene glycol)-b-(N-(2-benzoyloxypropyl) methacrylamide) (mPEG-HPMA-Bz) polymeric micelles and in Triton X-100 micelles was about 300-500 times more stable than in aqueous buffer. Therefore, loading of curcumin into polymeric micelles is a promising approach to stabilize this compound and develop formulations suitable for further pharmaceutical and clinical studies.
http://www.ncbi.nlm.nih.gov/pubmed/27038456
Hoping this will be helpful,
Rafik
Take care of the light and other radiative and non-radiative energy beams also! Any packing of the material should be in the dry nitrogen atmosphere or maintain the inert (noble gas) or nitrogen atmosphere in the vessel during experimentation. Would be better to bubble dry nitrogen gas in the preliminary solution/emulsion etc. containing the curcumin.
Stability of curcumin in water can be observed when you will use some commercialy available materials like gelucire, beta cyclodextrin etc. to encapsulate it. After encapsulation crystalline curcumin will be converted into amorphous form irreversibly. Above article suggested by Rafik sir will also help you to understand the stability of curcumin in water.
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