Which solvent can I use? I'm trying to dissolve PLA in chloroform, but I am getting some problems, can I use dichlomethane?
Hi,
Why don't you refer this paper?
http://onlinelibrary.wiley.com/doi/10.1002/app.38833/abstract
Jun Ling's answer is perfect, only thing I would like to add is that in order to accelerate the dissolution process, you can heat your solution for a finite amount of time.
Yes, I mean poly(lactide acid), but in a mixed of acetone/CHCl3 , but I have to use acetone ... :S and I don't want to degradate the polymer with heat I'm using emulsification/difussion method to do nanoparticles...
or I should dissolved first PLA in CHCl3 and then in acetone?? because some articles say that I have to mixed acetone and CHCl3 to equilibrate the system...
The DMF reacts with PLA. Regarding to the question of tatiana my personal suggestion is to dissolve first the PLA on Dichlorometane or chloroform and after add extra acetone to the desired concentration.
To mi knowledge the PLA is soluble on acetone but is not easy to dissolve in it,, but once the PLA is in solution is fully compatible with acetone.
Hi regarding to my last answer .. im not very sure about it. i mean I have seen something strange into PLA /DMF mixtures ... but dont know if if the plastificiser of my PLA or what ... :)
Jon Trifol: Yes, PLA can be soluble in chloroform, just I had to spend a little more time to dissolved it on it.. but it worked ;)
I dissolve my PLA in methylene chloride (dichloromethane), and then mix it with acetone when I make my nanoparticles. It takes some time and some heat, but I've been successful with it so far.
Semi-crystalline poly(L-lactic acid) can completely dissolve in chloroform and dichloromethane. Amorphous poly(D,L-lactic acid) can completely dissolve in acetone, THF, chlorofoem and dichloromethane.
It may take some time to dissolve PLA in DCM, especially for high MWs PLA . For PLA with MWs of 700,000,it took me 4-7 days to make a 5% PLA solution under stirring!
If you have trouble dissolving your polymer in a known solvent, try placing the sample in a sonicator and/or warm water bath.
I dissolve PLLA with chloroform. THF didn't work. Does anyone have experience with spin coating of dissolved PLLA?
You can dissolve either in chloroform solution or DCM solvent.Semi-crystalline poly(L-lactic acid) can completely dissolve in chloroform and dichloromethane. Amorphous poly(D,L-lactic acid) can completely dissolve in acetone, THF, chlorofoRm and dichloromethane.
Solve pla in moderate concentration in ch3cl and sonicate,
between 8-10 wt% is Ok.
I'm having some problems dissolving mPEG-PLGA... does anyone knows a good solvent for me? I tried with pure Acetone, a mixture of Acetone/Water or Acetone/MeOH with different ratio (2:1, 1:1, 1:2), Acetonitrile and a mixture Acetone/DCM 8:2... Nothing seems to really work :(
Dear sir,
Which solvent can i use ...?pls can i use dioxane .....
Valeria Gabrielli , You can try pure Chloroform or Dichloromethane. Both can work ...
PLA dissolution in chloroform is very slow (i.e. under vigorous stirring overnight), you can either use pure DCM or a chloroform/dichloromethane mixture.
Hi,
Why don't you refer this paper?
http://onlinelibrary.wiley.com/doi/10.1002/app.38833/abstract
Hi,
Some new experience about dissolving PLLA:
High Mw PLLA like Resomer L210S from Evonik dissolves quickly in chloroform but it may take even few days to dissolve it in DCM. After one thermal processing cycle (f.e. compression molding in 220 C deg.) Mw of PLLA drops 2 - 4 times and then it is easier to dissolve it.
Hi,
PLA is easily to be soluble in 2, 2, 2-triflouro ethanol (TFE) using water bath sonicator.
You can use a mixture of chloroform/dichloromethane under stiring.
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