I do not think real impactful research can be done by one person, especially these days where science is growing more and more complicated. It can be plausible for a review of the literature, but is very difficult for a high profile original paper.
It is very hard, or even impossible to conduct an original paper with high impact alone. You always need a team with members of different skills to be able to conduct all aspects needed for your project.
Depends upon the are of research and the topic one is handling.
If I am working on a multidisciplinary aspect, I must and I will collaborate and take the expert information from the person who is well versed in that stream.
Thank you Dr. Sandhyarani Khomdram, Abdelrahman Ibrahim Abushouk, Anas M. Saad and other great researchers, we need to draw strength together, just like the honey bees...