Question: I am currently developing a bioreactor model for hydrogen production using Aspen Custom Modeler (ACM). While I have basic knowledge of the software, I am seeking guidance from those with experience in ACM to help me progress effectively. Specifically, I would like to understand how to design the bioreactor and how to define unknown parameters such as Chemical Oxygen Demand (COD) and Biochemical Oxygen Demand (BOD). A step-by-step explanation or recommendations for helpful resources would be immensely appreciated. Additionally, any advice on calibrating and validating the model, particularly in scenarios with limited experimental data, would be extremely beneficial. Your insights and expertise would be invaluable in advancing my work on this project. Thank you for your support!