FMT is showing promising results in terms of treatment of recurrent gut infections. Could be used this approach (microbiota transplantation) for the management of chronic respiratory diseases with microbiological component such as COPD or CF?
Is there any research group that has tried to perform this procedure on the respiratory tree?
I see that the question is generating interest, please I would like to read your opinions!! :) @
Is the lung microbiota of individuals with chronic obstructive pulmonary disease (COPD) or cystic fibrosis (CF) distinct from normal/healthy lung microbiota?
Curr Opin Pulm Med. 2017 Sep;23(5):404-410.
Microbiome in interstitial lung disease: from pathogenesis to treatment target.
Salisbury ML et al.
Hi Martin Klvana , well our team has published some bibliography about COPD sputum microbiota (severe vs moderate patients), "Sputum microbiota in moderate vs severe patients with Chronic Obstructive Pulmonary Disease" and "Analysis of microbiota in stable patients with chronic obstructive pulmonary disease" in which we found differences in the microbiota between patients (COPD status) also in others pathologies of the respiratory tree "Nasopharyngeal Microbiota in Children With Invasive Pneumococcal Disease: Identification of Bacteria With Potential Disease-Promoting and Protective Effects". For this reason we are looking for information about respiratory microbiota interventions, maybe it would be an alternative to prolongated use of antibiotics... we are currently very far from being able to achieve that but it would be interesting to know if any research group is doing something similar. Thank you for your response.
Hi Christian G Meyer , thank you for the biblio I will check.
regards
theoretically , maybe done , but the diversity here completely differ from the intestinal microbial flora , where the holigenome may have future effect .
Wow!! nice concept Aziz Koleilat . Sure in the future we have to keep it in mind. Thank you for the response!!!
the pathological and histological status of any chronic disease is already formed and the changes are irreversible , and destruction is done , what we need maybe stem cell with the transfer,
I know of the GIT uses, but am excited by some of the reponses above.
Jennifer Hull , I am also excited I hope more people discuss this topic . Aziz Koleilat , regarding your answer. Well it is true in a chronic patient in the airway the tissue changes are irreversible (for example in COPD patients), but maybe with a respiratory microbiota transplant we could avoid in the future exacerbation events which are the cause of the tissue changes... if it would be possible it will be a good alternative to long term antibiotics in chronic diseases. Thank you for your answers.
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