Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases (free article from ACS)
https://pubs.acs.org/doi/full/10.1021/acscentsci.0c00272?utm_source=pubs_content_marketing&utm_medium=facebook&utm_campaign=0320_EJK_OCSpecialReportCOVID19&ref=pubs_content_marketing
The situation of COVID19 in N. Italy is out of control and it is more compatible with MERS / SARS. New treatments are urgent >>> https://www.researchgate.net/post/The_novel_Coronavirus_in_N_Italy_Lombardia_COVID19_2019nCoV_SARSCoV2_shows_a_fatality_rate_compatible_with_SARS_Why2
Article Acquired Long QT Syndrome: A Review of the Literature
This review discusses the points I outline below.
A note of caution.
Several medications that have been recommended for the treatment of Covid-19 are associated with prolongation of the QTc interval and therefore torsade de pointes and sudden cardiac death.
The evidence of the potential benefit of chloroquine and hydroxychloroquine in the treatment of Covid-19 is increasing.
Other medications which may be used in this cohort include the macrolide antibiotics (e.g. azithromycin). These can also prolong the QTc interval. Administering several medications that may prolong the QT interval is associated with a high risk of complications.
Article Acquired Long QT Syndrome: A Review of the Literature
In medicine risks and benefits must be balanced. Safety netting is important whenever there is a great potential benefit but also a very significant risk. In that context QTc intervals, renal and liver function must be monitored closely in patients treated with chloroquine and or macrolides. They should probably not be started if the baseline QTc is more than 450 ms. It should probably be stopped if the QTc increases 25% above baseline. It should definitely be stopped if QTc is above 500 ms. This is an evolving situation and recommendations may change as the potential risks and benefits become clearer.
Beta-blockade is used in the treatment of congenital and acquired long QT syndrome, so may be beneficial in this setting.
https://www.google.com/amp/s/www.bbc.com/news/amp/health-52111674
Please have a look at the link below:
Article Research and Development on Therapeutic Agents and Vaccines ...
Thank you prof Harasit for your contribution,
Unfortunately, it's indicated that is the title of a free research paper from ACS!
link has already provided in the post
kind regards
Dr. SAOUDI