Hi,
I have expression levels of 92 miRNAs (after filtering out low-abundance miRNAs) in 6 patients X 5 time points during drug treatment (baseline, day 7, day 14, day 21, day 30).
Now, I want to compare the levels on days 7, 14, 21, 30 to baseline for all miRNAs. Can I do repeated measure ANOVA with time and miRNA as factors, and then do pairwise comparisons within miRNAs for each time point vs baseline? I will of course corret for multiple comparisons, which makes it powerful because I have only 4 comparisons within miRNA.
An alternative is to correct for multiple miRNA within time points, but that will require testing many hypotheses. Are both ways legitimate?
Thanks
Iddo
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