Some studies proposed that corticosterone was inhibitory at earlier phase and enhances insulin secretion at late phase. Most of metabolic syndromes are involved with hyperaction of HPA axis, what will its effect be on insulin secretion?
Jean-Christophe Jonas
The effect of glucocorticoids on beta cells (insulin secretion, preproinsulin gene transcription) essentially differs between in vivo and in vitro conditions. In culture, their direct effect is inhibitory. In vivo, there are papers showing that beta cell are more sensitive to glucose in animals treated with GC due to the adaptation to insulin resistance (an indirect effect). So I think the question of the role of the HPA axis in metabolic syndrome and type 2 diabetes is worth investigating.
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