Dear all,
I'm formulating a dual delayed release drug with an acrylic resin coating and need recommendations for coprocessed excipients as filler/diluents. Any recommendation on commercially available cushioning agent coprocessed excipients?
i use this command: conda env create -n gmxMMPBSA --file env.yml and after waiting is always got killed like this: Channels: - conda-forge - bioconda - defaults Platform: linux-64 Collecting...
16 January 2024 2,319 1 View
I was performing free energy calculation using g_mmpbsa tools. From the summary data i got the value of binding energy, but when i check the output file, it shows only data energy for the complex....
27 November 2023 4,621 3 View
I have docked several ligand and protein and few of them have an unfavorable bump interaction. When we dock protein and ligand in Autodock-vina, they give us several output like out_ligand_1,...
29 August 2023 385 3 View
I have run a MD simulation of complex protein SIB1 (PDB ID: 7EAU) with several small molecules (ligand) using GROMACS and all of them show huge value of RMSD. Here i attached a google drive for...
08 August 2023 7,375 10 View
the command: python3 cgenff_charmm2gmx_py3_nx2.py UNL1 UNL_fix.mol2 UNL_fix.str charmm36-jul2022.ff error message: Traceback (most recent call last): File "cgenff_charmm2gmx_py3_nx2.py", line...
01 August 2023 4,865 2 View
I am working on Cell free DNA extraction from breast cancer patients. protocol was optimized. I wanted to quantify the cell free DnA extracted from the plasma . Kit used on qubit was Qubit dsDNA...
01 September 2020 6,198 1 View
Dear Researcher , can you please tell me that how is effectively using this kit mentioned above , i have procured this and trying to optimize the protocol but finding problem in DNA extraction in...
13 November 2019 2,781 0 View
I am to find out the quantification of circulating tumor DNA and cell free DNA through real time PCR, for that purpose in PCR which gene primers should be included for amplification
28 August 2019 5,644 4 View
I am using 4 pharmaceutical powders , particle size distribution is done before and after milling and repeated 3 times each.
14 August 2015 5,060 5 View
can any body help me in translated gamma process to approximate aggregate claims which is compound poisson? I wanna make simmulation using R..thank you very much.
01 April 2015 5,832 3 View
Are there any fluorescently labeled anti-Alpaca secondary antibodies raised in Donkey? So far I have only been able to find anti-Alpaca secondaries raised in Goat. Or is this not possible due to...
04 August 2024 4,255 1 View
Hi, I'm curious to know if data on chemical compounds from PubChem, such as water solubility properties, can be used to train a machine learning model for commercial purposes. Will this infringe...
30 July 2024 8,707 1 View
Hello everyone, I am currently working on a protein that is 10x his-tagged and positively charged (predicted pI=10.16). But when I tried to use Ni-NTA column to purify the protein, it's not...
24 July 2024 7,293 4 View
The resin bonded carbon containing refractories are aged before use. How time of aging is determined? And mechanism behind aging.
23 July 2024 3,205 0 View
Hello, I am experiencing an issue with mixing micro powder with resin in a 3D printer. The problem is that sedimentation occurs after a short period (about half an hour to an hour). Could you...
23 July 2024 1,672 0 View
https://en.wikipedia.org/wiki/Viscosity
21 July 2024 3,089 4 View
Dear Participants- Faculty and Researchers from Pakistani Higher Education Institutions, Thank you for participating in research study that aims to 'Analyze Individual and Institutional Factors...
18 July 2024 7,024 1 View
So i have a few peptides (synthesized by SPPS and not cleaved from resin) and I want to add a maleimide label. We have NHS-PEG-Maleimide and from literature it is evident that the free amine group...
18 July 2024 4,075 3 View
Good day everyone, Trying to perform protein purification for the first time, gotta buy the whole equipment/reagents. Protein of interest 48 kDa (Antithrombin), expressed from his-tagged plasmid...
16 July 2024 3,692 6 View
Even adding fragrance is not working
05 July 2024 741 2 View