Hi! Quick question: I know SD and Wistar rats have similar BG levels as humans, but I'm unable to find a model that would tolerate hypoglycemia well or had somewhat lower fasting BG levels per se. Any ideas? Thank you very much.
Tommy,
You might get more useful responses if you were to specify actual numbers as to what is your target hypoglycemia.
In our hands, Wistar rats can tolerate hypoglycemia quite well... ~25-40mg/dl with an occasional dip at below 20mg/dl (with obviously impaired ability to move).
Thank you very much Tausif.
You're right, I should have specified. From papers I have read the fasting BG of WIstar rats and other mouse models is slightly higher than in humans, and I was just looking for fasting BG levels around 80 mg/dl. Come to think of it, maybe it varies from animal model to animal model, and laboratory rats have generally higher BG, although they're easier to work with.
Anyway, based on what you're saying and papers about hypoglycemia, I think Wistar rats would do just fine. They were my first pick but if there is a model that naturally tolerates 40-50 mg/dl better, I would love to know.
Thank you all very much.
Article Hypoglycemic Brain Injury in the Rat: Correlation of Density...
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