Present literature is flooded with psoriasis terming it an autoimmune disease and a genetic disorder. Almost all patients visiting us opined that doctors, they visited, said that psoriasis can not be cured. Our experience with psoriasis treatment with Wrightia tinctoria is contrary to that. So far we treated over 1000 cases, which include 1. Erythrodermic psoriasis, 2. Pustular psoriasis, 3 Guttate psoriasis, 4. Scalp psoriasis, 5. Inverse pssoriasis, 6. Palmoplantar psoriasis, 7. Congenital psoriasis, 8. Infantile psoriasis, 9. Plaque psoriasis, 10. Papular psoriasis, 11 Psoriatic arthritis and 12. Nail psoriasis; and Bullous phempigoid and other diseases. The feed back from the patients suggest that psoriasis is cured. The psoriatic lesions disappeared in 3 months time followed by 3 months to normalize skin. The patients stopped herbal, but followed healthy diet and life style. The patients were advised to take healthy diet and drink, regular exercise, regular excretion, positive emotions, timely eating and early sleeping.
Dear Thammayya
There is overwhelming evidence that psoriasis has an important genetic component. Lomholt’s] classic epidemiological study of psoriasis in the Faroe Islands (1963), in which he examined more than 10 000 inhabitants, madethe key observation that the incidence of psoriasis was much greater amongst first- and second-degree relatives of patients than unaffected control subjects. A further large-scale study performed in Sweden supported these data, showing the prevalence of psoriasis to be 7.8% in first-degree relatives, compared with a prevalence of 3.14% in matched controls and 1.97% in the overall population. Based on population data, several investigators have calculated the risk for a child to develop psoriasis. In a German study, the risk was 14% if one parent was affected, 41% if both parents affected and 6% if one sibling affected, compared to 2% when no parent or sibling was affected]. Henseler and Christophers demonstrated that the bimodal peak in disease onset could be taken as evidence for the existence of two pathogenetically distinct forms of the disease, similar to the model for diabetes mellitus. Thus, type 1 is hereditary, strongly HLA associated (particularly HLA-Cw6), early onset and more likely to be severe. Type 2 is sporadic, HLA unrelated, of late onset and usually mild. A recent study in Iceland has confirmed many of these data . Environmental risk factors Present evidence indicates that interactions between genes and the environment are important in disease causation.
Trauma
Psoriasis at the site of an injury is well known (Koebner Phenomenon)
Infection
Acute guttate psoriasis is strongly associated with preceding or concurrent streptococcal infection, particularly of the throat.
Drugs
There are many drugs reported to be responsible for the onset or exacerbation of psoriasis .
Sunlight
Although sunlight is generally beneficial, in a small minority of patients, psoriasis may be provoked by strong sunlight.
Psychogenic factors
Considerable clinical evidence exists for the role of stress in onset and exacerbation of psoriasis.
Alcohol and smoking
It has long been suspected that both cigarettes and alcohol have a detrimental effect on psoriasis.
References
1 Eyre RW, Krueger GG. The Koebner response in psoriasis. In: Roenigk HH,
Maibach HI, eds. Psoriasis. New York: Marcel Dekker, 1984: 105–16.
2 Telfer NR, Chalmers RJ, Whale K, Colman G. The role of streptococcal
infection in the initiation of guttate psoriasis. Arch Dermatol 1992; 128:
39–42.
3 Tervaert WCC, Esseveld H. A study of the incidence of haemolytic streptococci
in the throat in patients with psoriasis vulgaris, with reference to their
role in the pathogenesis of this disease. Dermatologica 1970; 140: 282–90.
4 Naldi L, Peli L, Parazzini F, Carrel CF, Psoriasis Study Group of the Italian
Group for Epidemiological Research in Dermatology. Family history of
psoriasis, stressful life events, and recent infectious disease are risk factors
for a first episode of acute guttate psoriasis: results of a case–control study.
J Am Acad Dermatol 2001; 44: 433–8.
5 Martin BA, Chalmers RJ, Telfer NR. How great is the risk of further psoriasis
following a single episode of acute guttate psoriasis? Arch Dermatol
1996; 132: 717–8.
6 Abel EA, DiCicco LM, Orenberg EK et al. Drugs in exacerbation of psoriasis.
J Am Acad Dermatol 1986; 15: 1007–22.
An adult patient with psoriasis of 18 years duration got cured his skin lesions in 3 months time. He will continue treatment for another 3 months. He had no first or second degree relative with psoriasis. How these patients are getting cured of psoriasis?
Dear Thammayya, present evidence indicates that interactions between genes
and the environment are important in disease causation. Many environmental factors have been linked to psoriasis, and have been implicated in, for example, initiation of the disease process and exacerbation of pre-existing disease.
HEALTHY LIFE STYLE AND HEALTHY DIET and Wrightia tinctoria herbal are the answers to complete cure of autoimmune diseases. Chemicals as medicines are not the answer. Patients are spending lakhs of rupees in chemical medicines with no remedy even after decades.. Our body can cure if allowed to do so.
Please take a look at this useful RG link.
Article Genetics of psoriasis: a basis for precision medicine
Please also go through the following RG links.
Article Psoriasis Pathogenesis and Treatment
Article Combining Understanding of Immunological Mechanisms and Gene...
Article The Genetic Basis of Psoriasis