Nowadays the driving force(e- transition) of chemical reaction by enzymes are discovered in many cases. I thought by calculating the most appropriate e- transition route created by a certain structure comprised of aa sequence we can create artificial enzymes relatively easy. Is it technically possible and is there anyone using this method?(although I know that the underlying laws which connect aa sequence and protein structure are complicated and hard to utilize)
Check this study it's very interesting and relevant to your question
https://www.nature.com/articles/nchem.473
Vincent O. Nyangaresi Thanks. Tool of Optimization using computational analysis is developing fast and it will surely be the mainstream of structual biology.
In fact, there has been a lot of success in developing algorithms for designing protein from scratch. Sequence similarity implies structural similarity, but similar structures can also be found for proteins with different sequences because the structure is evolutionarily more conserved than the sequence. And the development of artificial intelligence neural networks will improve the accuracy of protein structure prediction.
https://www.creative-biostructure.com/De-Novo-Design-17.htm
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