Hi

Weighted genetic risk scores, defined as weighted sums of risk alleles of SNPs, are powerful statistical methods. To assign weights, the gold standard is to use external weights from an independent study. However, appropriate ones not always accessible. weighted GRS even with internal weights is a better alternative to single SNP approaches or the use of unweighted GRS, but might not be appropriate for detecting predominant E*G interactions. Therefore assigning weight logically can change the results.

Best regards