I am trying to assess change in protein conformation as a result of possible salt bridge formation and a couple of polar interactions. I wanted to know if using particle-mesh-Ewald electrostatics has an advantage over other coloumbtypes to study this? I am using Reaction-field-zero with infinite dielectric constant for this, because it was computationally less expensive (runs about 1.5x faster than PME).

This is being run in Gromacs 2020.2