I mean paradoxes, for example - a whale and a mouse; phenomenon salamanders (administered carcinogens formed not a tumor but an additional body organ); the phenomenon of spontaneous regression of cancer; cancer progression after detoxification, etc.
Do you mean Peto's Paradox? Peto, R.; Roe, F. J. C.; Lee, P. N.; Levy, L.; Clack, J. (October 1975). "Cancer and ageing in mice and men". British Journal of Cancer 32 (4): 411–426. doi:10.1038/bjc.1975.242. PMC 2024769. PMID 1212409.
Please foiiow this link.
en.wikipedia.org/wiki/Peto's_paradox
http://www.biomedcentral.com/1471-2407/7/151
To me, cancer paradoxes means a lot of different phenomena from molecular events to bedside care. For example, the attached papers report some paradoxical phenomenon in certain state of disease or mechanism.
Dear David Steensma and Abdul Halekue, it is as one of the paradoxes of cancer I had in mind (Peto's paradox).
Dear Victor C. Kok, thank you for your reference.
I would like to assemble a collection of some paradoxes of cancer. It seems to me, unresolved paradoxes are important for understanding the true nature of the disease of cancer.
I agree with you. I work with rat models of breast cáncer using carcinogens, and I always though that the answer was in the rats that do not develop tumors.... but where to look for?
Dear José Manuel Martínez-Martos. Frankly, we are currently working on the article on the pathogenesis of cancer and I would like to see our point of view on the pathogenesis of cancer could explain all ambiguities and paradoxes. Hope in May-June article is printed. So I am looking for any unnoticed me unexplained facts.
Hi,
interesting discussion...similar to the rat models: I am wondering about the fact, that most of my attempts to establish cell lines from clinical samples fail because most cells develop senescence in culture. "Unfortunately", if this is a general phenomenon- only the successfully established cultures are used in experiments and our knowledge about cancer strongly depends on these cell line models.
Dear Norman Hafner. I believe that cell cultures can only serve as models of individual processes in cancer because the cells are entirely dependent on external conditions. Mouse (like cancer model) is also heavily dependent on external conditions and their "autonomy" - largely a myth in the breaking of anthropocentric understanding of comfort.
Here's another paradox, which somehow does not meet the majority of the researchers: Why a cancer treatment is done by cancerogens?
I funny that many scientists avoid any answer to this question, and start to avoid me after this issue. It seems to me that question violates a cozy little world of artificial scientists who think they are scientists. Chemotherapy and radiotherapy is effective in the treatment of cancer, but the scientific basis to explain the mechanism of their therapeutic effect is largely mythological.
Another paradox is that nobody notices the difference in the frequency of spontaneous regression of cancer in animals and in humans. This difference is 100 000 times - 80% vs. 0.00071%.
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