Deuterated chloroform, methanol and water are the other most common deuterated solvents for NMR. It all depends on what your compound dissolves in.

Use Yang's suggested solvents-d, may be in mixture!

Selection of solvent system for NMR totally depends on the type of testing compound in which your sample completely dissolve. Various deuterated solvents are used in single or  mixture form of DMSO, CDCl3 and D2O which affect polarity system for making the solution of your compound. 

Should I make mixtures of or need to try separately?

But thanks very much, Eugene, Riaz and Shivani for your beneficial answers

Thanks Riaz, but what should I keep the ratio of the MIXTURE? any idea please

For exact mixture ratio, you will need to run trials for solubility, the d-solvents are a bit more solubilizer! Can start with measured volume of  base solvent for your sample (the least you can handle for 5 mg of your sample;, Hope NMR is powerful enough in MHz sense, usually about 400 MHz for best NMR results). It would be wise if you avid hydrophilic solvents as the base but add the hydrophilic solvents slowly (preferably drop wise from a measured solvent stock) and see the solubility. The base volume can be to fill the NMR tube to the requisite NMR experiment run and later you can adjust the ratio since the base has the complete fill of the tube and added hydrophobic solvent is add on which will overflow! You can also try random ratios like 5-50% v/v . If you have the initial idea about the solubility of your test compound, it would be easy to go and make a hit and trial!

Riaz A. Khan Thank you very much.

Dear Mr. Ali,

The solvent selection depends on the solubility of your compound. If you need any alternative of DMSO, first you should try to check solubility of your compound in a different solvent (without deuterated).

Still, there is some information below which may help you: 

CDCl3 - This solvent has good purity, dissolve many compounds and is the primary solvent used.

Acetone-d6 - A great solvent, not too expensive, although not as polar as others.

CD2Cl2 - This solvent is excellent. Ideal for low-temperature chemistry.

Toluene-d8 - Very good for low and high-temperature work

CD3CN - This is usually a good choice when a more polar solvent is needed.

DMSO-d6 - This is usually a poor choice although it is not expensive.

THF-d8 - This solvent is expensive.

Source: https://web.nmsu.edu/~kburke/Instrumentation/NMR_Solv.html

You may try Methanol-d4 also.

Best wishes

Lot of thanks  Anup Kumar Singh,

You also provided me a very much useful answer. 

 Common available  deuteriated  CDCl3 , Acetone-d6, THF-d8  , DMSO-d6 , can be 

used as the polar solvents for polar compounds  for scanning NMR . Trifluocetic acid can be used fixing OH signal as std. at about 10.5 delta .

Thank you very much,

Madhukar Baburao Deshmukh

Well wishes

So, which one worked and what was the product? Did you get a nice, unhindered NMR (P or C)?

Hello dear Riaz A. Khan,

Because of the busy schedule I didn't apply yet but I will apply the same concepts step-wise which were provided by you all here.

I thank you all..

My best wishes

Hello dear all,

I hope you all will be good and happy, relative to the concerned question that I asked before I did some trials just two samples dissolved completely in CDCl3 besides other samples. Beyond, I tried Acetone-d6, Acetone-d6 + D2O, pure D2O etc but didn't solve any of the sample.

[Here I don't have these deuterated THF, CDCL2, DMSO and like solvents].

Anyone have his/her kind response because this made me really confused.

My best wishes and thanksgivings.

Hi Dear Ali,

Would you like to mention if you need the NMR to confirm your product formation or you are going to paste it in the journal article?

Also, do you have CDCl3 with you?

Regards

Anup

Dear Anup Kumar Singh, I work with NMR, I don't work with any synthesis or Isolation. So, I have some samples, which I am trying to analyze but lack of DMSO-d6 that's why I am facing such problem as well.

Well wishes.

Hi Dear Ali,

If there is no such a question about publishing the NMR data of your interest. You may first dissolve the compound in the minimum possible amount of normal solvent in which it is soluble, then mix it with the deuterated solvent of your interest (whatever compatible deuterated solvent you have). You will get some extra solvent peak, but you may be able to analyze the compound.

Best wishes