Increase incidence of bladder cancer seen with high dose30mg/d with pioglitazone. At low dose7.5mg/d carcinogenic property not seen with good effect on diabetes control. It is cost effective drug with having unique antiatherosclerotic property.
Pioglitazone may be associated with an increased risk of bladder cancer. Tell your doctor right away if you notice symptoms that could be associated with bladder cancer (eg, a red color or blood in the urine, difficult or painful urination, an increased need to urinate). Discuss any questions or concerns with your doctor.