As India enters the third COVID-19 wave, the anti-viral drug Molnupiravir was quickly launched for use in mild-moderate illness with a high risk of progressing to severe disease. There is however skepticism about its efficacy in real-life situations.
What is the experience of those who used it first hand? Is there any real-life data on its use, especially from countries already gone through a third wave?
Dear Prof. Dayal!
I did my best to search for resources that may be of value for YOU:
1) Pourkarim F, Pourtaghi-Anvarian S, Rezaee H. Molnupiravir: A new candidate for COVID-19 treatment. Pharmacol Res Perspect. 2022;10:e00909. doi:10.1002/prp2.909 Open access: Article Molnupiravir: A new candidate for COVID‐19 treatment
2) Clare Wilson 2021. UK has begun using drugs for covid-19 cases before they become severe, 24 December 2021, © Copyright New Scientist Ltd. Free access:
https://www.newscientist.com/article/2302731-uk-has-begun-using-drugs-for-covid-19-cases-before-they-become-severe/
3) Max Kozlov 2021.Merck’s COVID pill loses its lustre: what that means for the pandemic: Molnupiravir was initially heralded by public-health officials as a game-changer for COVID-19, but full clinical-trial data showed lower-than-expected efficacy. Nature News 13, December 2021, Free access: https://www.nature.com/articles/d41586-021-03667-0
4) Richard Whitley 2021. Molnupiravir — A Step toward Orally Bioavailable Therapies for Covid-19, 16 December 2021, Copyright © 2022 Massachusetts Medical Society. Free access: Article Molnupiravir — A Step toward Orally Bioavailable Therapies f...
5) Angélica Jayk Bernal et al. 2021. Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients, 16 December 2021, DOI: 10.1056/NEJMoa2116044 Copyright © 2022 Massachusetts Medical Society. Free access: https://www.nejm.org/doi/full/10.1056/NEJMoa2116044?query=recirc_curatedRelated_article
Yours sincerely, Bulcsu Szekely
It is not yet available where I work. Am looking forward to testing this.
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