Approaches for read-across can provide a practical alternative for safety assessment of compounds which have similar structures or result in the same major metabolites.

"Read-across exploits information on structurally related (similar) analogues to derive hypotheses about the activity of the new chemical and hence predict its toxicity without experimental testing."

https://www.ecetoc.org/taskforce/approaches-for-read-across-in-chemical-risk-assessment/

Thanks for this answer. I understand that this is a normal procedure in the risk assessment of chemicals, although not for the worst toxins. I assume that it works better in the assessment of toxicity than in potential environmental effects. For example, different freons have a big difference in their effect on the ozone layer.

Hi Jan, is there possible for you to do the assesment for genotoxic compound?

Hi, I am not doing any assessments myself. I am just here trying to get some general idea on how to speed up the assessment of chemicals to decrease the backlog of unscreened chemicals.

an IPCC for chemicals could also be of help? https://genevasolutions.news/climate/could-an-ipcc-for-chemicals-save-us-from-poisoning-the-planet

Thank you for your helpful comments, I used them successfully in this just-published article. Unfortunately, there was no space for thanks, in a short commentary like this so this will be my THANKS! https://pubs.acs.org/doi/10.1021/acs.est.2c00524